ERADICATION OF HELICOBACTER PYLORI

Eradication of Helicobacter Pylori

General idea.The article is a review of data on Helicobacter pylori resistance to antibiotics, the impact of CYP2C19 polymorphism on the metabolism of proton pump inhibitors, and recent findings on the 133x4 effectiveness of eradication.The authors conclude that triple therapy (proton pump inhibitor + clarithromycin + amoxicillin) is still the best

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Unlocking the bottleneck in forward genetics using whole-genome sequencing and identity by descent to isolate causative mutations.

Forward genetics screens with N-ethyl-N-nitrosourea (ENU) provide a powerful way to illuminate gene function and generate mouse models of human disease; however, the identification of causative mutations remains a limiting step.Current strategies depend on conventional mapping, so the propagation of affected mice requires non-lethal screens; accura

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